| Registro completo |
| Provedor de dados: |
ArchiMer
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| País: |
France
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| Título: |
High temperature induces transcriptomic changes in Crassostrea gigas that hinder progress of ostreid herpesvirus (OsHV-1) and promote survival
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| Autores: |
Delisle, Lizenn
Pauletto, Marianna
Vidal-dupiol, Jeremie
Petton, Bruno
Bargelloni, Luca
Montagnani, Caroline
Pernet, Fabrice
Corporeau, Charlotte
Fleury, Elodie
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| Data: |
2020-10
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| Ano: |
2020
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| Palavras-chave: |
Anti-viral molecular pathway
Host-pathogen interaction
Marine disease
OsHV-1
Resistance
Temperature
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| Resumo: |
Of all environmental factors, seawater temperature plays a decisive role in triggering marine diseases. Like fever in vertebrates, high seawater temperature could modulate the host response to pathogens in ectothermic animals. In France, massive mortality of Pacific oysters, Crassostrea gigas, caused by the ostreid herpesvirus 1 (OsHV-1) is markedly reduced when temperatures exceed 24°C in the field. In the present study we assess how high temperature influences the host response to the pathogen by comparing transcriptomes (RNA sequencing) during the course of experimental infection at 21°C (reference) and 29°C. We show that high temperature induced host physiological processes that are unfavorable to the viral infection. Temperature influenced the expression of transcripts related to the immune process and increased the transcription of genes related to the apoptotic process, synaptic signaling and protein processes at 29°C. Concomitantly, the expression of genes associated with catabolism, metabolite transport, macromolecule synthesis and cell growth remained low from the first stage of infection at 29°C. Moreover, viral entry into the host might have been limited at 29°C by changes in extracellular matrix composition and protein abundance. Overall, these results provide new insights into how environmental factors modulate host–pathogen interactions.
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| Tipo: |
Text
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| Idioma: |
Inglês
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| Identificador: |
https://archimer.ifremer.fr/doc/00656/76806/77974.pdf
DOI:10.1242/jeb.226233
https://archimer.ifremer.fr/doc/00656/76806/
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| Editor: |
The Company of Biologists
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| Relação: |
info:eu-repo/grantAgreement/EC/FP7/678589/EU//VIVALDI
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| Formato: |
application/pdf
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| Fonte: |
Journal Of Experimental Biology (0022-0949) (The Company of Biologists), 2020-10 , Vol. 223 , N. 20 , P. jeb226233 (11p.)
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| Direitos: |
info:eu-repo/semantics/openAccess
restricted use
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